Preheat oven to 400ºF (205ºC). Line 2 large baking sheets with parchment paper.
Combine the water, butter and salt in a medium-sized saucepan. Bring to a boil over medium heat. Reduce the heat. Add the flour and stir vigorously with a wooden spoon until the mixture pulls away from sides of pan and forms a ball.
Transfer the mixture to the bowl of a stand mixer. Mix on low speed until steam dissipates and mixture cools to lukewarm. Add the eggs one at a time and beat on medium speed until smooth, stopping to scrape down the bowl.
Transfer the mixture to a piping bag fitted with a large round tip. (I used Ateco tip 808.*) Pipe 1 1/4-inch mounds, about 2 inches apart, onto the prepared baking sheets. Smooth the tops lightly with a wet finger.
Bake for 15 minutes, then turn down the oven heat to 350ºF (180ºC) and continue baking until golden brown, about 8-10 more minutes. Using a toothpick or skewer, prick a small hole in each profiterole to allow steam to escape. Place on a wire rack to cool completely.
Use the tip of a paring knife to make a pilot hole in the bottom of each profiterole.
Place strawberries and cream filling into a piping bag fitted with a medium round piping tip. (I used Wilton tip 12**) Place the tip into the pilot holes and fill each profiterole with filling.